| 1 | University of Cincinnati College of Medicine Cincinnati, OH | Cincinnati, Ohio | 3.1% | 519 | 3.88 | $39,168 |
| 2 | University of Minnesota Medical School Minneapolis, MN | Minneapolis, Minnesota | 4% | 518 | 3.85 | $44,290 |
| 3 | University of Chicago Division of the Biological Sciences The Pritzker School of Medicine Chicago, IL | Chicago, Illinois | 2.6% | 522 | 3.94 | $63,403 |
| 4 | Northwestern University The Feinberg School of Medicine Chicago, IL | Chicago, Illinois | 3.4% | 521 | 3.92 | $57,854 |
| 5 | Case Western Reserve University School of MedicineIMG-Friendly Cleveland, OH | Cleveland, Ohio | 4.5% | 520 | 3.87 | $55,817 |
| 6 | Washington University in St. Louis School of Medicine Saint Louis, MO | Saint Louis, Missouri | 2.5% | 522 | 3.94 | $53,121 |
| 7 | Indiana University School of Medicine Indianapolis, IN | Indianapolis, Indiana | 4.9% | 516 | 3.81 | $35,773 |
| 8 | Rush Medical College of Rush University Medical CenterIMG-Friendly Chicago, IL | Chicago, Illinois | 4.2% | 518 | 3.84 | $56,032 |
| 9 | Mayo Clinic Alix School of Medicine Rochester, MN | Rochester, Minnesota | 2.4% | 521 | 3.92 | $60,146 |
| 10 | Saint Louis University School of Medicine Saint Louis, MO | Saint Louis, Missouri | 4% | 518 | 3.85 | $55,239 |
| 11 | University of Kansas School of Medicine Kansas City, KS | Kansas City, Kansas | 5% | 516 | 3.79 | $43,304 |
| 12 | Medical College of Wisconsin Milwaukee, WI | Milwaukee, Wisconsin | 4.7% | 516 | 3.8 | $53,080 |
| 13 | Ohio State University College of Medicine Columbus, OH | Columbus, Ohio | 4.8% | 517 | 3.81 | $41,543 |
| 14 | University of Missouri-Columbia School of Medicine Columbia, MO | Columbia, Missouri | 5.3% | 515 | 3.77 | $43,799 |
| 15 | University of Wisconsin School of Medicine and Public Health Madison, WI | Madison, Wisconsin | 5.2% | 516 | 3.78 | $35,086 |
| 16 | University of Iowa Roy J. and Lucille A. Carver College of Medicine Iowa City, IA | Iowa City, Iowa | 5.2% | 516 | 3.78 | $36,563 |
| 17 | University of North Dakota School of Medicine and Health SciencesIMG-Friendly Grand Forks, ND | Grand Forks, North Dakota | 5.9% | 514 | 3.75 | $42,487 |
| 18 | Loyola University Chicago Stritch School of Medicine Maywood, IL | Maywood, Illinois | 5.4% | 515 | 3.76 | $50,930 |
| 19 | University of Michigan Medical SchoolIMG-Friendly Ann Arbor, MI | Ann Arbor, Michigan | 3.9% | 519 | 3.86 | $42,759 |
| 20 | University of South Dakota, Sanford School of MedicineIMG-Friendly Sioux Falls, SD | Sioux Falls, South Dakota | 6.5% | 513 | 3.73 | $37,916 |
| 21 | Michigan State University College of Human MedicineIMG-Friendly East Lansing, MI | East Lansing, Michigan | 6.3% | 514 | 3.74 | $36,615 |
| 22 | University of Nebraska College of Medicine Omaha, NE | Omaha, Nebraska | 6.1% | 514 | 3.74 | $43,788 |
| 23 | Northeast Ohio Medical University Rootstown, OH | Rootstown, Ohio | 6.5% | 514 | 3.73 | $44,508 |
| 24 | The University of Toledo College of Medicine and Life Sciences Toledo, OH | Toledo, Ohio | 6.6% | 513 | 3.73 | $42,074 |
| 25 | Kansas City University College of Osteopathic Medicine Kansas City, MO | Kansas City, Missouri | 9.4% | 509 | 3.62 | $56,606 |
| 26 | University of Missouri-Kansas City School of MedicineIMG-Friendly Kansas City, MO | Kansas City, Missouri | 7.8% | 511 | 3.67 | $42,450 |
| 27 | Central Michigan University College of Medicine Saginaw, MI | Saginaw, Michigan | 8.2% | 511 | 3.68 | $42,741 |
| 28 | Wayne State University School of Medicine Detroit, MI | Detroit, Michigan | 8.2% | 511 | 3.67 | $43,079 |
| 29 | University of Illinois College of Medicine Chicago, IL | Chicago, Illinois | 7.8% | 512 | 3.69 | $40,597 |
| 30 | Oakland University William Beaumont School of Medicine Rochester, MI | Rochester, Michigan | 7.9% | 512 | 3.69 | $35,864 |
| 31 | Southern Illinois University School of Medicine Springfield, IL | Springfield, Illinois | 8.7% | 510 | 3.66 | $40,277 |
| 32 | Creighton University School of MedicineIMG-Friendly Omaha, NE | Omaha, Nebraska | 7.8% | 512 | 3.71 | $53,229 |
| 33 | Wright State University Boonshoft School of Medicine Dayton, OH | Dayton, Ohio | 8.6% | 510 | 3.66 | $35,069 |
| 34 | Chicago Medical School at Rosalind Franklin University of Medicine & ScienceIMG-Friendly North Chicago, IL | North Chicago, Illinois | 8.6% | 511 | 3.66 | $57,450 |
| 35 | Western Michigan University Homer Stryker M.D. School of Medicine Kalamazoo, MI | Kalamazoo, Michigan | 8.9% | 510 | 3.65 | $60,913 |
| 36 | Carle Illinois College of MedicineIMG-Friendly Urbana, IL | Urbana, Illinois | 9.1% | 511 | 3.67 | $38,165 |
| 37 | A.T. Still University Kirksville College of Osteopathic Medicine Kirksville, MO | Kirksville, Missouri | 12.2% | 506 | 3.55 | $53,582 |
| 38 | Michigan State University College of Osteopathic Medicine East Lansing, MI | East Lansing, Michigan | 11.9% | 506 | 3.56 | $54,636 |
| 39 | Ohio University Heritage College of Osteopathic MedicineIMG-Friendly Athens, OH | Athens, Ohio | 13.7% | 505 | 3.52 | $48,600 |
| 40 | Kansas Health Science Center–Kansas College of Osteopathic Medicine Wichita, KS | Wichita, Kansas | 15.6% | 503 | 3.49 | $63,465 |
| 41 | Marian University College of Osteopathic MedicineIMG-Friendly Indianapolis, IN | Indianapolis, Indiana | 14% | 504 | 3.51 | $49,102 |
| 42 | Midwestern University Chicago College of Osteopathic MedicineIMG-Friendly Downers Grove, IL | Downers Grove, Illinois | 14.5% | 504 | 3.5 | $62,388 |
| 43 | Des Moines University College of Osteopathic Medicine Des Moines, IA | Des Moines, Iowa | 12.8% | 506 | 3.56 | $64,393 |